List of pop culture references to Powerpuff Girls

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Powerpuff Girls has become a pop culture phenomenon since its debut in 1998, with the three little girls (Blossom, Bubbles, and Buttercup) who protect the city of Townsville from the forces of crime with their awesome superpowers before bedtime.

TV series

Amphibia

• "The Hardest Thing:" When taking flight their calamity forms, Anne, Sasha, and Marcy each leave a trail of the same distinctive colors as the Powerpuff Girls do.

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Mad

Main article: Mad

The Middle

• "Valentine's Day:" Frankie hands out several Valentine's Day cards Brick can use, which include Buzz Lightyear and Powerpuff Girls, although the cards are only seen from the back.

My Little Pony: Friendship is Magic

• "Power Ponies:" Dressed like superheroes, the ponies and Spike have defeated Mane-iac, when Spike says, "Once again, the day is saved by..." Similar to the Narrator's final speech at the end of every episode of the original series.

My Wife and Kids

• "He Said, She Said:" Kyle asks Kady what her plans are for the day, which are to watch Powerpuff Girls, but since Kyle was already planning on watching a basketball game, he lies to her and says she can't because the Powerpuff Girls are watching the same basketball game.
• "What Do You Know?:" In a couples game of "What Do You Know?," Kady asks Franklin who her favorite Powerpuff Girl is, but Franklin, knowing nothing about them, responds with a bunch of random names that don't belong to any of the girls, which includes Barney, Pinky, Trixie, Twinky, Lucky, and Sticky.

Robot Chicken

Main article: Robot Chicken

The Simpsons

Main article: The Simpsons

Teen Titans Go!

Main article: Teen Titans Go!

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Video games

MultiVersus

Main article: MultiVersus

• Townsville appears as a stage.