Wilma Flintstone

Wilma Flintstone is the tritagonist of the Flintstones franchise. Wilma is a cavewoman and a stay at home wife for her husband, Fred. Wilma must always contend with Fred's temper, usually caused by work or money she needs, which usually ends with him looking like a jackass.

Not including The Flagstones pitch, Wilma's official first appearance was in The Flintstones episode "The Flintstone Flyer". The voice originated from Jean Vander Pyl.

American Dad!

 * "Stan of Arabia: Part 1": She appears in a fantasy dancing with Stan, along with other fictional TV wives of the Golden Age of television who knew their place, as Stan doesn't want a partner in Francine, just a wife.
 * "Of Ice and Men": Roger the alien wears is dressed like Wilma at the end of the episode.